Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions
نویسندگان
چکیده
منابع مشابه
Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy.
OBJECTIVES This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using technetium-99m-labeled broad matrix metalloproteinase inhibitor (MPI) and to determine the effect of dietary modification and statin treatment on MMP activity. BACKGROUND The MMP activity in atherosclerotic lesions contributes to th...
متن کاملNoninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography.
Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage patients empirically, or worse, after plaque rupture. Noninvasive imaging of the molecular events signaling prerupture plaque progression has t...
متن کاملExpression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase
Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) would produce a histologically stable lesion by limiting macrophage enrichment and thereby a source of matrix metalloproteinases (MMPs). Male New Zealand White rabbits were sequentially fed a cholesterol/fat diet for 9 ...
متن کاملThe ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits.
Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) would produce a histologically stable lesion by limiting macrophage enrichment and thereby a source of matrix metalloproteinases (MMPs). Male New Zealand White rabbits were sequentially fed a cholesterol/fat diet for 9 ...
متن کاملNuclear Imaging of Vulnerable Atherosclerotic Lesions
Coronary artery disease is the most important cardiovascular scourage that mankind has faced in the twentieth century. It will continue to be the leading cause of morbidity and death in the next century, both in men and women, and in developing and developed nations alike. The management of coronary artery disease has almost always been based on demonstration of the severity of luminal stenosis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2008
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2008.08.048